John Constantine's decaying body and deteriorating soul put him in an inescapable predicament. As a banished soul, he faced oblivion if he were found dead in America. His fate rested on solving the enigma surrounding his deteriorating body and securing the assistance of fellow believers to avert his gruesome demise.

John Constantine, despite his valiant efforts to evade death throughout his life, will eventually succumb to its relentless grip. His decaying body and impending death will leave him without the solace of an afterlife, leaving him to face oblivion without hope of redemption.
As of John Constantine, Hellblazer: Dead in America #1 by Simon Spurrier and Aaron Campbell, John's heart has stopped beating, and he remains motionless. His existence in America is marked by a chilling emptiness that reveals the severity of the fatal condition. Dream of the Endless reveals that if John dies in America, his fate will be unbearable, and his soul will be obliterated.
John Constantine has consistently crossed boundaries and defied fate, engaging with both the supernatural and the divine. While he has made deals with demons and angels, he has consistently avoided fulfilling his side of the bargain when he can. His presence in both Heaven and Hell has been forbidden, with him being banned from both realms for his actions. The concept of his soul vanishing and being trapped in limbo or oblivion has been explored numerous times in various DC storylines.
If John Constantine wants to avoid being found dead in America, he's going to need to gather new allies and solve the mystery of why his body is rotting from the inside out. While avoiding death has always been a powerful motivator for John, he now has to fight something far scarier than just death. John has dealt with tons of ghosts over the years — and has even been one in a few stories — but if John Constantine dies now, there won't be anything left of him to be a ghost, especially if every version of the afterlife refuses him.